Identification and characterization of Sr13, a tetraploid wheat gene that confers resistance to the Ug99 stem rust race group.
Identifieur interne : 000515 ( Main/Exploration ); précédent : 000514; suivant : 000516Identification and characterization of Sr13, a tetraploid wheat gene that confers resistance to the Ug99 stem rust race group.
Auteurs : Wenjun Zhang [États-Unis] ; Shisheng Chen [États-Unis] ; Zewdie Abate [États-Unis] ; Jayaveeramuthu Nirmala [États-Unis] ; Matthew N. Rouse [États-Unis] ; Jorge Dubcovsky [États-Unis]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2017.
Descripteurs français
- KwdFr :
- Basidiomycota (génétique), Chromosomes de plante (génétique), Gènes de plante (génétique), Haplotypes (génétique), Maladies des plantes (génétique), Régulation négative (génétique), Régulation positive (génétique), Résistance à la maladie (génétique), Tiges de plante (génétique), Triticum (génétique), Tétraploïdie (MeSH).
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
The Puccinia graminis f. sp. tritici (Pgt) Ug99 race group is virulent to most stem rust resistance genes currently deployed in wheat and poses a threat to global wheat production. The durum wheat (Triticum turgidum ssp. durum) gene Sr13 confers resistance to Ug99 and other virulent races, and is more effective at high temperatures. Using map-based cloning, we delimited a candidate region including two linked genes encoding coiled-coil nucleotide-binding leucine-rich repeat proteins designated CNL3 and CNL13. Three independent truncation mutations identified in each of these genes demonstrated that only CNL13 was required for Ug99 resistance. Transformation of an 8-kb genomic sequence including CNL13 into the susceptible wheat variety Fielder was sufficient to confer resistance to Ug99, confirming that CNL13 is Sr13CNL13 transcripts were slightly down-regulated 2-6 days after Pgt inoculation and were not affected by temperature. By contrast, six pathogenesis-related (PR) genes were up-regulated at high temperatures only when both Sr13 and Pgt were present, suggesting that they may contribute to the high temperature resistance mechanism. We identified three Sr13-resistant haplotypes, which were present in one-third of cultivated emmer and durum wheats but absent in most tested common wheats (Triticum aestivum). These results suggest that Sr13 can be used to improve Ug99 resistance in a large proportion of modern wheat cultivars. To accelerate its deployment, we developed a diagnostic marker for Sr13 The identification of Sr13 expands the number of Pgt-resistance genes that can be incorporated into multigene transgenic cassettes to control this devastating disease.
DOI: 10.1073/pnas.1706277114
PubMed: 29078294
PubMed Central: PMC5692537
Affiliations:
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The durum wheat (<i>Triticum turgidum</i> ssp. <i>durum</i>) gene <i>Sr13</i> confers resistance to Ug99 and other virulent races, and is more effective at high temperatures. Using map-based cloning, we delimited a candidate region including two linked genes encoding coiled-coil nucleotide-binding leucine-rich repeat proteins designated CNL3 and CNL13. Three independent truncation mutations identified in each of these genes demonstrated that only <i>CNL13</i> was required for Ug99 resistance. Transformation of an 8-kb genomic sequence including <i>CNL13</i> into the susceptible wheat variety Fielder was sufficient to confer resistance to Ug99, confirming that <i>CNL13</i> is <i>Sr13</i><i>CNL13</i> transcripts were slightly down-regulated 2-6 days after <i>Pgt</i> inoculation and were not affected by temperature. By contrast, six pathogenesis-related (<i>PR</i>) genes were up-regulated at high temperatures only when both <i>Sr13</i> and <i>Pgt</i> were present, suggesting that they may contribute to the high temperature resistance mechanism. We identified three <i>Sr13</i>-resistant haplotypes, which were present in one-third of cultivated emmer and durum wheats but absent in most tested common wheats (<i>Triticum aestivum</i>). These results suggest that <i>Sr13</i> can be used to improve Ug99 resistance in a large proportion of modern wheat cultivars. To accelerate its deployment, we developed a diagnostic marker for <i>Sr13</i> The identification of <i>Sr13</i> expands the number of <i>Pgt</i>-resistance genes that can be incorporated into multigene transgenic cassettes to control this devastating disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29078294</PMID><DateCompleted><Year>2018</Year><Month>06</Month><Day>19</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN><JournalIssue CitedMedium="Internet"><Volume>114</Volume><Issue>45</Issue><PubDate><Year>2017</Year><Month>11</Month><Day>07</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation></Journal><ArticleTitle>Identification and characterization of <i>Sr13</i>, a tetraploid wheat gene that confers resistance to the Ug99 stem rust race group.</ArticleTitle><Pagination><MedlinePgn>E9483-E9492</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.1706277114</ELocationID><Abstract><AbstractText>The <i>Puccinia graminis</i> f. sp. <i>tritici</i> (<i>Pgt</i>) Ug99 race group is virulent to most stem rust resistance genes currently deployed in wheat and poses a threat to global wheat production. The durum wheat (<i>Triticum turgidum</i> ssp. <i>durum</i>) gene <i>Sr13</i> confers resistance to Ug99 and other virulent races, and is more effective at high temperatures. Using map-based cloning, we delimited a candidate region including two linked genes encoding coiled-coil nucleotide-binding leucine-rich repeat proteins designated CNL3 and CNL13. Three independent truncation mutations identified in each of these genes demonstrated that only <i>CNL13</i> was required for Ug99 resistance. Transformation of an 8-kb genomic sequence including <i>CNL13</i> into the susceptible wheat variety Fielder was sufficient to confer resistance to Ug99, confirming that <i>CNL13</i> is <i>Sr13</i><i>CNL13</i> transcripts were slightly down-regulated 2-6 days after <i>Pgt</i> inoculation and were not affected by temperature. By contrast, six pathogenesis-related (<i>PR</i>) genes were up-regulated at high temperatures only when both <i>Sr13</i> and <i>Pgt</i> were present, suggesting that they may contribute to the high temperature resistance mechanism. We identified three <i>Sr13</i>-resistant haplotypes, which were present in one-third of cultivated emmer and durum wheats but absent in most tested common wheats (<i>Triticum aestivum</i>). These results suggest that <i>Sr13</i> can be used to improve Ug99 resistance in a large proportion of modern wheat cultivars. To accelerate its deployment, we developed a diagnostic marker for <i>Sr13</i> The identification of <i>Sr13</i> expands the number of <i>Pgt</i>-resistance genes that can be incorporated into multigene transgenic cassettes to control this devastating disease.</AbstractText><CopyrightInformation>Copyright © 2017 the Author(s). Published by PNAS.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Wenjun</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Plant Sciences, University of California, Davis, CA 95616.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Shisheng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Plant Sciences, University of California, Davis, CA 95616.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abate</LastName><ForeName>Zewdie</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Plant Sciences, University of California, Davis, CA 95616.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nirmala</LastName><ForeName>Jayaveeramuthu</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, University of Minnesota, St. Paul, MN 55108.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouse</LastName><ForeName>Matthew N</ForeName><Initials>MN</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, University of Minnesota, St. Paul, MN 55108; matthew.rouse@ars.usda.gov jdubcovsky@ucdavis.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>US Department of Agriculture-Agricultural Research Service, Cereal Disease Laboratory, University of Minnesota, St. Paul, MN 55108.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubcovsky</LastName><ForeName>Jorge</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-7571-4345</Identifier><AffiliationInfo><Affiliation>Department of Plant Sciences, University of California, Davis, CA 95616; matthew.rouse@ars.usda.gov jdubcovsky@ucdavis.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Howard Hughes Medical Institute, Chevy Chase, MD 20815.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>KY825225</AccessionNumber><AccessionNumber>KY825235</AccessionNumber><AccessionNumber>KY924305</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><Acronym>HHMI</Acronym><Agency>Howard Hughes Medical Institute</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Proc Natl Acad Sci U S A</MedlineTA><NlmUniqueID>7505876</NlmUniqueID><ISSNLinking>0027-8424</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001487" MajorTopicYN="N">Basidiomycota</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032461" MajorTopicYN="N">Chromosomes, Plant</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060467" MajorTopicYN="N">Disease Resistance</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017343" MajorTopicYN="N">Genes, Plant</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006239" MajorTopicYN="N">Haplotypes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018547" MajorTopicYN="N">Plant Stems</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057891" MajorTopicYN="N">Tetraploidy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014908" MajorTopicYN="N">Triticum</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">CC-NBS-LRR</Keyword><Keyword MajorTopicYN="Y">Ug99</Keyword><Keyword MajorTopicYN="Y">durum wheat</Keyword><Keyword MajorTopicYN="Y">resistance genes</Keyword><Keyword MajorTopicYN="Y">stem rust</Keyword></KeywordList><CoiStatement>The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>6</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29078294</ArticleId><ArticleId 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IdType="pubmed">27251721</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Maryland</li><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Zhang, Wenjun" sort="Zhang, Wenjun" uniqKey="Zhang W" first="Wenjun" last="Zhang">Wenjun Zhang</name></region><name sortKey="Abate, Zewdie" sort="Abate, Zewdie" uniqKey="Abate Z" first="Zewdie" last="Abate">Zewdie Abate</name><name sortKey="Chen, Shisheng" sort="Chen, Shisheng" uniqKey="Chen S" first="Shisheng" last="Chen">Shisheng Chen</name><name sortKey="Dubcovsky, Jorge" sort="Dubcovsky, Jorge" uniqKey="Dubcovsky J" first="Jorge" last="Dubcovsky">Jorge Dubcovsky</name><name sortKey="Dubcovsky, Jorge" sort="Dubcovsky, Jorge" uniqKey="Dubcovsky J" first="Jorge" last="Dubcovsky">Jorge Dubcovsky</name><name sortKey="Nirmala, Jayaveeramuthu" sort="Nirmala, Jayaveeramuthu" uniqKey="Nirmala J" first="Jayaveeramuthu" last="Nirmala">Jayaveeramuthu Nirmala</name><name sortKey="Rouse, Matthew N" sort="Rouse, Matthew N" uniqKey="Rouse M" first="Matthew N" last="Rouse">Matthew N. 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